MacroDIS

KAIROS has developed and continues to maintain several digital imaging spectrophotometers on-site which are capable of imaging macroscopic targets from 1 millimeter to 1 meter in size over a spectral range from 400 nm to 950 nm. MacroDIS, previously known as the ColonyImager, embodies many of the features described for MicroDIS and FIMS. 

The figure shown below demonstrates the interactive user interface of MacroDIS. An image of a Petri dish from which spectra were acquired is shown in the upper left window. The current feature of interest is marked by a small white cursor. The spectrum of this colony (410 - 910 nm) is plotted in the lower left window and its pseudocolored absorption spectrum (marked by the red bar next to the Contour Plot) is shown on the right. Each row of the Contour Plot represents a different colony whose x, y information is stored by the software. Similar to the spectrum in the conventional plot window, wavelength is represented on the horizontal axis. However, absorbance is now color coded according to the colorbar at the bottom. The PC's mouse can be used to point to any colony in the image window or to any row in the Contour Plot with a real time update of all three windows. 112 spectra corresponding to 112 colonies from nine different strains of Rb. capsulatus are shown. Spectral bands in the 400 - 500 nm range are due to carotenoids, while those in the near infrared (700 - 900 nm) are due to the interaction of bacteriochlorophyll and bacteriopheophytin with different protein complexes.

A screen capture of the MacroDIS user interface, where a similarity sort reveals that nine different types of mutants are on the Petri dish.

Prototype versions of MacroDIS were used to produce many of the graphics displayed in General Interest section of this website.

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